DRUG SENSITIVITY

It has been known for some time that some Collies experienced an adverse reaction to certain drugs of which Ivermectin, although not licensed for dogs, was possible the most commonly used. Recent research has indicated that this is caused by a gene mutation sometime in our early history which also affects related breeds, and that the problem is not confined to Ivermectin but embraces a whole subgroup of drugs, many of which are licensed for dogs, that are used in a wide spectrum of illnesses. We strongly advise owners read the label for active ingredients before purchasing over the counter medications, and as many vets remain ignorant about this development it is up to the owner to ensure that under no circumstances must any of the following active ingredients be used on a Collie, without first ensuring that the Collie does not carry the defect  MDR-1  gene.

 

Acepromazine
Butorphanol
Chinidin
Cyclosporin
Dexamethasone
Digoxin
Domperidone
Doxorubicin
Ebastine
Erythromycin
Etoposide
Grepafloxacin
Hydrocortisone
Ivermectin
Loperamide
Mitoxantrone
Morphine
Moxidectin
Ondansetron
Paclitaxe
Quinidine
Rifampicin
Selamectin
Sparfloxacin
Tacrolimus
Vinblastine
Vincristine

 

(PDF documents)

Drug Sensitivity

MDR1 Factsheet

MDR1 letter for vet

MDR1leaflet